Efficient, “Tin-Free” Radical Cyclization to Aromatic Systems. Synthesis of 5,6,8,9,10,11- Hexahydroindolo[2,1-a]isoquinolines

Efficient radical cyclization of alkyl iodides to various aromatic systems including pyrrole, indole, isoquinolone, pyridone, and benzene, mediated by dicumyl peroxide, is described. The methodology was used to provide access to 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinoline derivatives.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2004-05, Vol.69 (11), p.4001-4004
Hauptverfasser:	Menes-Arzate, Martha, Martínez, Roberto, Cruz-Almanza, Raymundo, Muchowski, Joseph M, Osornio, Yazmin M, Miranda, Luis D
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	Efficient radical cyclization of alkyl iodides to various aromatic systems including pyrrole, indole, isoquinolone, pyridone, and benzene, mediated by dicumyl peroxide, is described. The methodology was used to provide access to 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinoline derivatives.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo0497048