Requirement of ryanodine receptors for pacemaker Ca2+ activity in ICC and HEK293 cells

Intracellular Ca(2+) ([Ca(2+)](i)) oscillations seen in interstitial cells of Cajal (ICCs) are considered to be the primary pacemaker activity in the gut. Here, we show evidence that periodic Ca(2+) release from intracellular Ca(2+) stores produces [Ca(2+)](i) oscillations in ICCs, using cell cluste...

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Veröffentlicht in:	Journal of cell science 2004-06, Vol.117 (Pt 13), p.2813-2825
Hauptverfasser:	Aoyama, Masahiro, Yamada, Aki, Wang, Jing, Ohya, Susumu, Furuzono, Shinji, Goto, Takayo, Hotta, Shingo, Ito, Yasushi, Matsubara, Tatsuaki, Shimokata, Kaoru, Chen, S R Wayne, Imaizumi, Yuji, Nakayama, Shinsuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - pharmacology Animals Biological Clocks - drug effects Biological Clocks - physiology Boron Compounds - pharmacology Caffeine - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Cell Line Enzyme Inhibitors - pharmacology Fluorescent Antibody Technique, Indirect Fluorescent Dyes Fura-2 Humans Ileum - cytology Ileum - metabolism Immunohistochemistry Kinetics Macrocyclic Compounds Mice Microscopy, Fluorescence Muscle, Smooth - cytology Muscle, Smooth - metabolism Nifedipine - pharmacology Oxazoles - pharmacology Proto-Oncogene Proteins c-kit - metabolism RNA, Messenger - metabolism Ryanodine - metabolism Ryanodine - pharmacology Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Tacrolimus - pharmacology Tetracaine - pharmacology
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