Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25

Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25 Maggie C.Y. Ng 1 2 , Wing-Yee So 1 , Nancy J. Cox 3 4 , Vincent K.L. Lam 1 , Clive S. Cockram 1 , Julian A.J.H. Critchley 1 † , Graeme I. Bell 2 3 4 and Juliana C.N. Chan 1 1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 2 Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 3 Department of Human Genetics, University of Chicago, Chicago, Illinois 4 Department of Medicine, University of Chicago, Chicago, Illinois Address correspondence and reprint requests to Dr. Maggie C.Y. Ng, Howard Hughes Medical Institute, University of Chicago, 5841 S. Maryland Ave., MC1028, Chicago, IL 60637. E-mail: maggieng{at}uchicago.edu Abstract We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong Kong Chinese population. We studied 64 families, segregating type 2 diabetes, of which 57 had at least one member with an age at diagnosis of ≤40 years. These families included a total of 126 affected sibpairs and 4 other affected relative pairs. Nonparametric linkage analysis revealed seven regions showing nominal evidence for linkage with type 2 diabetes (logarithm of odds [LOD] >0.59, P pointwise < 0.05): chromosome 1 at 173.9 cM (LOD = 3.09), chromosome 3 at 26.3 cM (LOD = 1.27), chromosome 4 at 135.3 cM (LOD = 2.63), chromosome 5 at 139.3 cM (LOD = 0.84), chromosome 6 at 178.9 cM (LOD = 1.91), chromosome 12 at 48.7 cM (LOD = 1.99), and chromosome 18 at 28.1 cM (LOD = 1.00). Simulation studies showed genome-wide significant evidence for linkage of the chromosome 1 region ( P genome-wide = 0.036). We have confirmed the results of previous studies for the presence of a susceptibility locus on chromosome 1q21-q25 (173.9 cM) and suggest the locations of other loci that may contribute to the development of type 2 diabetes in Hong Kong Chinese. GIT, glucose intolerance ILR, independent linked region LOD, logarithm of odds Footnotes † † J.A.J.H.C. passed away in 2001. Additional information for this article can be found in an online appendix at http://diabetes.diabetesjournals.org . Accepted March 8, 2004. Received March 5, 2004. DIABETES