Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain

More than 20 matrix metalloproteinases (MMPs) and four of their endogenous tissue inhibitors (TIMPs) act together to control tightly temporally restricted, focal proteolysis of extracellular matrix. In the neurons of the adult brain several components of the TIMP/MMP system are expressed and are res...

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Veröffentlicht in:	FEBS Letters 2004-06, Vol.567 (1), p.129-135
Hauptverfasser:	Dzwonek, Joanna, Rylski, Marcin, Kaczmarek, Leszek
Format:	Artikel
Sprache:	eng
Schlagworte:	A2RE, A2 response element AD, Alzheimer's disease Adult ALS, amyotrophic lateral sclerosis BDNF, brain-derived neurotrophic factor Brain Brain - enzymology Brain - metabolism CA, cornu Ammoni CDV, canine distemper virus CNS, central nervous system CREB, cAMP responsive element binding (protein, a transcription factor) CSPG, chondroitin sulfate proteoglycan DG, dentate gyrus ECM, extracellular matrix ECS, electroconvulsive seizures ER, endoplasmic reticulum HSPG, heparan sulfate proteoglycan Humans KA, kainate L1, outer layer of the cerebral cortex Long term potentiation LRP, low-density lipoprotein receptor-related protein LTP, long term potentiation Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors Matrix metalloproteinase-9 Matrix Metalloproteinases - physiology Memory MMP, matrix metalloproteinase Models, Biological MT-MMP, membrane-type matrix metalloproteinase Neuron Neuronal plasticity Neurons - enzymology Neurons - metabolism NGF, nerve growth factor NO, nitric oxide PD, Parkinson's disease PGs, proteoglycans RT-PCR, reverse-transcriptase polymerase chain reaction TIMP, tissue inhibitor of matrix metalloproteinases Tissue Inhibitor of Metalloproteinases - metabolism Tissue Inhibitor of Metalloproteinases - physiology tPA, tissue plasminogen activator uPA, urokinase plasminogen activator uPAR, uPAR receptor
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Zusammenfassung:	More than 20 matrix metalloproteinases (MMPs) and four of their endogenous tissue inhibitors (TIMPs) act together to control tightly temporally restricted, focal proteolysis of extracellular matrix. In the neurons of the adult brain several components of the TIMP/MMP system are expressed and are responsive to changes in neuronal activity. Furthermore, functional studies, especially involving blocking of MMP activities, along with the identification of MMP substrates in the brain strongly suggest that this enzymatic system plays an important physiological role in adult brain neurons, possibly being pivotal for neuronal plasticity.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/j.febslet.2004.03.070