What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element b...

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Veröffentlicht in:	Microbes and Infection 2004-05, Vol.6 (6), p.630-636
Hauptverfasser:	Bastos, Karina R.B., Marinho, Claudio R.F., Barboza, Renato, Russo, Momtchilo, Álvarez, José M., D’Império Lima, Maria Regina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Biological and medical sciences Dendritic cell Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology Humans IFN-γ IL-12 IL-23 Interleukin-12 - immunology Interleukin-12 - physiology Interleukin-23 Interleukin-23 Subunit p19 Interleukins - immunology Interleukins - physiology Macrophage Macrophage Activation Macrophages - immunology Microbiology Nitric oxide Signal Transduction TGF-β1
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Beschreibung
Zusammenfassung:	The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element between accessory cells and lymphocytes, but it is also a key molecule for programming the macrophage and dendritic cell functions.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2004.02.012