Role of endogenous adenosine as a modulator of syncope induced during tilt testing

Previous reports that used head-up tilt testing and adenosine administration have suggested that adenosine may be an important endogenous mediator that may trigger a vasovagal response in susceptible patients. However, little is known regarding endogenous adenosine plasma levels (APLs) during vasovagal syncope provoked by tilt testing. The aim of this study was to determine whether APLs differ in patients with a positive head-up tilt test compared with those with a negative test and whether APLs are modified during tilt-induced vasovagal syncope. APLs (mean+/-SEM) were measured during head-up tilt test in 26 patients who presented with unexplained syncope. In the 15 patients with a negative test, APLs were 0.39+/-0.03 micromol/L at baseline, 0.22+/-0.03 micromol/L immediately after tilting, and 0.44+/-0.03 micromol/L after 45 minutes. APLs were significantly higher in the 11 patients with a positive test (2.66+/-0.67 micromol/L at baseline and 3.22+/-0.85 micromol/L immediately after tilting) than in those with a negative test. During tilt testing-induced syncope, APLs increased to reach 4.03+/-0.66 micromol/L (ie, a 52% increase compared with baseline levels; P