Yeast go the whole HOG for the hyperosmotic response

An evolutionarily conserved mitogen-activated protein kinase pathway – the high osmolarity glycerol (HOG) pathway – mediates the hyperosmotic response in Saccharomyces cerevisiae. A variety of powerful approaches has generated a comprehensive picture of how cells respond to this stress condition. Several presumptive osmosensors on the cell surface recruit and activate downstream signaling components, which regulate the activity of transcription factors to control gene expression. A variety of powerful approaches has generated a comprehensive picture of how Saccharomyces cerevisiae cells respond to hyperosmotic stress through an evolutionarily conserved mitogen-activated kinase pathway.