Single nucleotide polymorphism seeking long term association with complex disease

Successful investigation of common diseases requires advances in our understanding of the organization of the genome. Linkage disequilibrium provides a theoretical basis for performing candidate gene or whole‐genome association studies to analyze complex disease. However, to constructively interroga...

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Veröffentlicht in:Nucleic acids research 2002-08, Vol.30 (15), p.3295-3311
Hauptverfasser: Kirk, Brian W., Feinsod, Matthew, Favis, Reyna, Kliman, Richard M., Barany, Francis
Format: Artikel
Sprache:eng
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Zusammenfassung:Successful investigation of common diseases requires advances in our understanding of the organization of the genome. Linkage disequilibrium provides a theoretical basis for performing candidate gene or whole‐genome association studies to analyze complex disease. However, to constructively interrogate SNPs for these studies, technologies with sufficient throughput and sensitivity are required. A plethora of suitable and reliable methods have been developed, each of which has its own unique advantage. The characteristics of the most promising genotyping and polymorphism scanning technologies are presented. These technologies are examined both in the context of complex disease investigation and in their capacity to face the unique physical and molecular challenges (allele amplification, loss of heterozygosity and stromal contamination) of solid tumor research.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gkf466