Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells

Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on...

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Veröffentlicht in:	Fitoterapia 2004-06, Vol.75 (3-4), p.261-266
Hauptverfasser:	Kim, Hyung-Jin, Jang, Seon Il, Kim, Young-Jun, Chung, Hun-Taeg, Yun, Yong-Gab, Kang, Tai-Hyun, Jeong, Ok-Sam, Kim, Youn-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Artemisia Cell Line - drug effects Cyclooxygenase 2 Dinoprostone - metabolism Dose-Response Relationship, Drug Interleukin-1 - metabolism Interleukin-6 - metabolism Isoenzymes - metabolism Lipopolysaccharides Macrophages - drug effects Macrophages - metabolism Mice Phytotherapy Prostaglandin-Endoperoxide Synthases - metabolism Scopoletin - administration & dosage Scopoletin - pharmacology Scopoletin - therapeutic use Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE2 production through the depression of COX-2 expression.
ISSN:	0367-326X
DOI:	10.1016/j.fitote.2003.12.021