Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women

Background: Many of the benefits of soy have been attributed to soy isoflavones. Objective: The objective was to determine the effects of high- and low-isoflavone soy-protein foods on both lipid and nonlipid risk factors for coronary artery disease (CAD). Methods: Forty-one hyperlipidemic men and po...

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Veröffentlicht in:	The American journal of clinical nutrition 2002-08, Vol.76 (2), p.365-372
Hauptverfasser:	Jenkins, David J.A, Kendall, Cyril W.C, Jackson, Chung-Ja C, Connelly, Philip W, Parker, Tina, Faulkner, Dorothea, Vidgen, Edward, Cunnane, Stephen C, Leiter, Lawrence A, Josse, Robert G
Format:	Artikel
Sprache:	eng
Schlagworte:	apolipoprotein B Biological and medical sciences Blood blood lipids Blood Pressure - drug effects Cardiovascular disease cholesterol Cholesterol - blood Coronary Disease - prevention & control coronary vessels Cross-Over Studies Diet Dietary Proteins - therapeutic use Disorders of blood lipids. Hyperlipoproteinemia Dose-Response Relationship, Drug Female gender differences high density lipoprotein cholesterol homocysteine Homocysteine - blood Humans Hyperlipidemias - drug therapy isoflavones Isoflavones - administration & dosage Isoflavones - therapeutic use Lipids Lipids - blood low density lipoprotein low fat dairy products Male Medical sciences men Metabolic diseases Middle Aged Postmenopause Proteins risk risk factors Soy products soy protein Soybean Proteins - administration & dosage Soybean Proteins - therapeutic use systolic blood pressure women
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Zusammenfassung:	Background: Many of the benefits of soy have been attributed to soy isoflavones. Objective: The objective was to determine the effects of high- and low-isoflavone soy-protein foods on both lipid and nonlipid risk factors for coronary artery disease (CAD). Methods: Forty-one hyperlipidemic men and postmenopausal women participated in a study with three 1-mo diets: a low-fat dairy food control diet and high- (50 g soy protein and 73 mg isoflavones daily) and low- (52 g soy protein and 10 mg isoflavones daily) isoflavone soyfood diets. All 3 diets were very low in saturated fat (
ISSN:	0002-9165 1938-3207
DOI:	10.1093/ajcn/76.2.365