DNA binding and 3'-5' exonuclease activity in the murine alternatively-spliced p53 protein

In this study we show that the naturally occurring C-terminally alternative spliced p53 (referred to as AS-p53) is active as a sequence-specific DNA binding protein as well as a 3'-5'-exonuclease in the presence of Mg2+ ions. The two activities are positively correlated as the sequence-spe...

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Veröffentlicht in:	Oncogene 2002-08, Vol.21 (33), p.5117-5126
Hauptverfasser:	SHAKKED, Zippora, YAVNILOVITCH, Michael, KALB, A. Joseph, KESSLER, Naama, WOLKOWICZ, Roland, ROTTER, Varda, HARAN, Tali E
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Alternative Splicing - genetics Amino acid sequence Animals Apoptosis Base Sequence Binding sites Binding, Competitive Biological and medical sciences Biology Biotechnology Cell cycle Deoxyribonucleic acid DNA DNA - metabolism Electrophoretic Mobility Shift Assay Escherichia coli Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Exonuclease Fundamental and applied biological sciences. Psychology Gene therapy Genomes Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Magnesium Mice Mobility Mutation Nucleotide sequence p53 Protein Phosphorothioate Protein Binding Proteins Substrate Specificity Time Factors Transcription factors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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