Influence of 3D-CRT pelvic irradiation on outcome in prostate cancer treated with external beam radiotherapy

Purpose : The role of pelvic irradiation (PRT) in the treatment of prostate cancer remains unclear. We reviewed our institution’s experience with three-dimensional conformal external beam radiotherapy (3D-CRT) during the prostate-specific antigen era to determine the influence of PRT on the risk of...

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Veröffentlicht in:International journal of radiation oncology, biology, physics biology, physics, 2002-08, Vol.53 (5), p.1139-1145
Hauptverfasser: Pan, C.C, Kim, K.Y, Taylor, J.M.G, McLaughlin, P.W, Sandler, H.M
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Sprache:eng
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Zusammenfassung:Purpose : The role of pelvic irradiation (PRT) in the treatment of prostate cancer remains unclear. We reviewed our institution’s experience with three-dimensional conformal external beam radiotherapy (3D-CRT) during the prostate-specific antigen era to determine the influence of PRT on the risk of biochemical recurrence in patients who have a predicted risk of lymph node involvement. Methods and Materials : Between March 1985 and January 2001, 1832 patients with clinically localized prostate cancer were treated with definitive 3D-CRT. All treatments involved CT planning to ensure coverage of the intended targets. Treatment consisted of prostate-only treatment, prostate and seminal vesicle treatment, or PRT of lymph nodes at risk followed by a boost. To create relatively homogenous analysis groups, each patient’s percentage of risk of lymph node (%rLN) involvement was assigned by matching the patient’s T stage, Gleason score, and initial prostate-specific antigen level to the appropriate value as described in the updated Partin tables. Three categories of %rLN involvement were defined: low, 0–5%; intermediate, >5–15%; and high, >15%. Biochemical recurrence was defined as the first occurrence of either the American Society for Therapeutic Radiology and Oncology consensus definition of prostate-specific antigen failure or the initiation of salvage hormonal therapy for any reason. Results : The risk status (%rLN) could be determined for 709 low-risk, 263 intermediate-risk, and 309 high-risk patients. The actuarial freedom from biochemical recurrence (bNED) and the log-rank test for the similarity of the control and treatment survival functions are reported for each risk group. Multivariate analysis demonstrated a statistically significant benefit for the entire population treated with PRT, with a relative risk reduction of 0.72 (95% confidence interval 0.54–0.97). Although the multivariate analysis could not determine the patient population that would most benefit from PRT, the beneficial effect appeared to be most pronounced within the intermediate-risk group. Univariate analysis revealed that the intermediate-risk patients treated with PRT had an improved 2-year bNED rate, 90.1% vs. 80.6% ( p = 0.02), and both low-risk and high-risk patients treated with PRT had statistically similar 2-year bNED rates compared with those who did not receive it. Conclusion : Pelvic 3D-CRT appears to improve bNED in prostate cancer patients. Additional studies are needed to e
ISSN:0360-3016
1879-355X
DOI:10.1016/S0360-3016(02)02818-3