In vitro SAR of (5-(2 H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase

A series of (5-(2 H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes. A series of (5-(2 H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of poten...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-06, Vol.14 (12), p.3155-3159
Hauptverfasser:	Lowe, Derek B., Magnuson, Steven, Qi, Ning, Campbell, Ann-Marie, Cook, James, Hong, Zhenqiu, Wang, Ming, Rodriguez, Mareli, Achebe, Furahi, Kluender, Harold, Wong, Wai C., Bullock, William H., Salhanick, Arthur I., Witman-Jones, Terri, Bowling, Mary E., Keiper, Christine, Clairmont, Kevin B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Diabetes Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology HSL Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Isoxazoles - chemistry Isoxazoles - pharmacology Lipase Lipolysis Medical sciences Miscellaneous Pharmacology. Drug treatments Sterol Esterase - antagonists & inhibitors Sterol Esterase - metabolism Structure-Activity Relationship Urea - chemistry Urea - pharmacology
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Zusammenfassung:	A series of (5-(2 H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes. A series of (5-(2 H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.04.015