Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragments

Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragments. In view of recent reports of large amounts of albumin fragments present in normal urine we investigated the mechanism of albumin handling by the proximal tubule. We injected 125I-albumin intravenously...

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Veröffentlicht in:	Kidney international 2004-06, Vol.65 (6), p.2113-2122
Hauptverfasser:	Gudehithlu, Krishnamurthy P., Pegoraro, Alfredo A., Dunea, George, Arruda, Jose A.L., Singh, Ashok K.
Format:	Artikel
Sprache:	eng
Schlagworte:	albumin albumin catabolism albumin endocytosis albumin receptor Animals Biological and medical sciences Cell Line Chloroquine - pharmacology degraded albumin Endocytosis Humans In Vitro Techniques Injections, Intravenous Iodine Radioisotopes Kidney - drug effects Kidney - metabolism Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - metabolism Male Medical sciences megalin Molecular Weight Nephrology. Urinary tract diseases Peptide Fragments - chemistry Peptide Fragments - metabolism Peptide Fragments - urine Perfusion proximal tubular cell Radioimmunoassay Rats Rats, Sprague-Dawley Serum Albumin - administration & dosage Serum Albumin - metabolism
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