HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China

Summary Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR–sequence‐specific primers to genotype polymorphisms in HLA‐DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of D...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical and experimental dermatology 2002-06, Vol.27 (4), p.319-321
Hauptverfasser: Gao, X.-H., Winsey, S., Li, G., Barnardo, M, Zhu, X.-J., Chen, H.-D., Song, F., Zhai, N., Fuggle, S., Wojnarowska, F.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Summary Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR–sequence‐specific primers to genotype polymorphisms in HLA‐DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P 
ISSN:0307-6938
1365-2230
DOI:10.1046/j.1365-2230.2002.01037.x