HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China
Summary Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR–sequence‐specific primers to genotype polymorphisms in HLA‐DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of D...
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Veröffentlicht in: | Clinical and experimental dermatology 2002-06, Vol.27 (4), p.319-321 |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Summary Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR–sequence‐specific primers to genotype polymorphisms in HLA‐DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P |
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ISSN: | 0307-6938 1365-2230 |
DOI: | 10.1046/j.1365-2230.2002.01037.x |