Image contrast agents activated by prostate specific antigen (PSA)

The viability of a three-component enzyme activated image contrast system was demonstrated using a family of tyrosine–chromophore conjugates linked by an inert spacer. A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent acti...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-06, Vol.14 (12), p.3081-3084
Hauptverfasser:	Jones, Graham B., Xie, Longfei, El-Shafey, Ahmed, Crasto, Curtis F., Bubley, Glenn J., D’Amico, Anthony V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Contrast Media - chemistry Contrast Media - metabolism Medical sciences Miscellaneous Pharmacology. Drug treatments Prostate-Specific Antigen - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The viability of a three-component enzyme activated image contrast system was demonstrated using a family of tyrosine–chromophore conjugates linked by an inert spacer. A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen and α-chymotrypsin, releasing free fluorophore via cleavage of a three-component system.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.04.041