Shooting the messenger of antibiotic resistance: Plasmid elimination as a potential counter-evolutionary tactic

Plasmids mediating antibiotic resistance (and virulence) might be interesting targets for anti-infective therapy. However, any compound produced using this strategy must be used carefully.

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Bibliographische Detailangaben
Veröffentlicht in:	Drug discovery today 2004-06, Vol.9 (11), p.465-467
Hauptverfasser:	Amábile-Cuevas, Carlos F, Heinemann, Jack A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use anti-bacterial targets antibiotic resistance Bacteria - drug effects Bacteria - genetics Bacterial Infections - drug therapy Drug Design Drug Resistance, Microbial - genetics Drug Resistance, Multiple - genetics Gene Transfer, Horizontal horizontal gene transfer plasmid elimination plasmids Plasmids - drug effects virulence
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Beschreibung
Zusammenfassung:	Plasmids mediating antibiotic resistance (and virulence) might be interesting targets for anti-infective therapy. However, any compound produced using this strategy must be used carefully.
ISSN:	1359-6446 1878-5832
DOI:	10.1016/S1359-6446(03)02989-1