Characterization of a novel MICA allele, MICA047
: We report the identification of a novel MICA allele, MICA*047. It was initially detected because of an unusual hybridization pattern with sequence‐specific oligonucleotides (SSOP) in a normal subject of Caucasian origin. Cloning and sequencing of both strands, and comparison of the sequence with p...
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Veröffentlicht in: | Tissue antigens 2002-04, Vol.59 (4), p.308-310 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | : We report the identification of a novel MICA allele, MICA*047. It was initially detected because of an unusual hybridization pattern with sequence‐specific oligonucleotides (SSOP) in a normal subject of Caucasian origin. Cloning and sequencing of both strands, and comparison of the sequence with previously defined MICA alleles, revealed that the new allele is similar to MICA*041 except for one nucleotide substitution at position 811 (C→G). It appears that this new allele could have been generated by an interallelic sequence exchange between MICA*011 and MICA*0411. |
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ISSN: | 0001-2815 1399-0039 |
DOI: | 10.1034/j.1399-0039.2002.590409.x |