DOWNREGULATION OF BOTH INTERLEUKIN-12 AND INTERLEUKIN-2 IN HEART ALLOGRAFTS BY PRETRANSPLANT HOST TREATMENT WITH GRANULOCYTE COLONY-STIMULATING FACTOR AND TACROLIMUS

Since recombinant human granulocyte colony-stimulating factor (rhG-CSF) has been reported to induce immune deviation, we examined the effects of pretransplant treatment of recipients with rhG-CSF on heart allograft survival. Before heterotopic heart transplantation from DA to Lewis rats, recipients...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2002-05, Vol.18 (3), p.164-167
Hauptverfasser:	Egi, Hiroyuki, Hayamizu, Keisuke, Kitayama, Teruhiko, Ohmori, Ichiro, Okajima, Masazumi, Asahara, Toshimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Down-Regulation - drug effects Granulocyte Colony-Stimulating Factor - pharmacology granulocyte colony-stimulating factor/interleukin-10/interleukin-12/interleukin-2/tacrolimus Heart Transplantation - immunology Humans Interleukin-12 - genetics Interleukin-12 Subunit p35 Interleukin-2 - genetics Male Protein Subunits - genetics Rats Rats, Inbred Lew Recombinant Proteins - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism Tacrolimus - pharmacology Transplantation, Homologous
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Zusammenfassung:	Since recombinant human granulocyte colony-stimulating factor (rhG-CSF) has been reported to induce immune deviation, we examined the effects of pretransplant treatment of recipients with rhG-CSF on heart allograft survival. Before heterotopic heart transplantation from DA to Lewis rats, recipients were given rhG-CSF (125μg/kg s.c. twice a day from day −5 to 0) and/or tacrolimus (2mg/kg i.m. on day 0). Combined treatment with both rhG-CSF and tacrolimus prolonged graft survival significantly (P
ISSN:	1043-4666 1096-0023
DOI:	10.1006/cyto.2002.0887