N-Thiolated β-Lactams: novel antibacterial agents for methicillin-Resistant Staphylococcus aureus

N-Methylthio-substituted β-lactams comprise a novel family of antibacterial agents that display high selectivity for MRSA as well as unusual SAR features and a mode of action. In this report we describe a new family of N-thiolated β-lactams that have antibacterial activity against methicillin-resist...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-08, Vol.12 (16), p.2229-2231
Hauptverfasser:	Turos, Edward, Long, Timothy E., Konaklieva, Monika I., Coates, Cristina, Shim, Jeung-Yeop, Dickey, Sonja, Lim, Daniel V., Cannons, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Lactams Biological and medical sciences Medical sciences Methicillin Resistance Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Staphylococcus aureus - drug effects Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	N-Methylthio-substituted β-lactams comprise a novel family of antibacterial agents that display high selectivity for MRSA as well as unusual SAR features and a mode of action. In this report we describe a new family of N-thiolated β-lactams that have antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The compounds show unprecedented structure–activity features and an unusual mode of action for a β-lactam antibiotic.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(02)00343-8