Ci Proteolysis: Regulation by a Constellation of Phosphorylation Sites

Ci Proteolysis: Regulation by a Constellation of Phosphorylation Sites

Proteolytic processing of Ci requires phosphorylation by the kinases Sgg/GSK3 and CK1. The newly identified phosphorylation sites form clusters with previously described PKA sites in which phosphorylation by PKA acts to prime subsequent phosphorylation by Sgg/GSK3 and CK1.

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Bibliographische Detailangaben
Veröffentlicht in:Current biology 2002-06, Vol.12 (12), p.R422-R423
Hauptverfasser: Lefers, Mark A, Holmgren, Robert
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Binding Sites
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Casein Kinases
DNA-Binding Proteins - metabolism
Drosophila
Drosophila Proteins
Glycogen Synthase Kinase 3
Molecular Sequence Data
Phosphorylation
Protein Kinases - metabolism
Protein-Serine-Threonine Kinases - metabolism
Transcription Factors
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Beschreibung
Zusammenfassung:Proteolytic processing of Ci requires phosphorylation by the kinases Sgg/GSK3 and CK1. The newly identified phosphorylation sites form clusters with previously described PKA sites in which phosphorylation by PKA acts to prime subsequent phosphorylation by Sgg/GSK3 and CK1.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(02)00914-4