Sympathetic-renal interaction in chronic arterial pressure control

Departments of 1 Physiology, 2 Clinical Chemistry, and 3 Pathology, Ernst-Moritz-Arndt-University, D-17487 Greifswald, Germany The effects of neonatal sympathectomy of donors or recipients on posttransplantation arterial pressure were investigated in spontaneously hypertensive rats (SHR) by renal...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-08, Vol.283 (2), p.441-R450
Hauptverfasser:	Grisk, Olaf, Rose, Hans-Joachim, Lorenz, Gerd, Rettig, Rainer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Arteriosclerosis - etiology Arteriosclerosis - pathology Arteriosclerosis - physiopathology Blood Pressure - drug effects Blood Pressure - physiology Body Weight - physiology Creatinine - blood Crosses, Genetic Disease Progression Diuresis - drug effects Drinking Guanethidine Heart Rate Hydralazine - pharmacology Hypertension, Renal - etiology Hypertension, Renal - physiopathology Kidney - drug effects Kidney - innervation Kidney - pathology Kidney - physiopathology Kidney Transplantation - adverse effects Male Natriuresis - drug effects Norepinephrine - blood Organ Size - physiology Rats Rats, Inbred SHR Rats, Inbred WKY Sodium, Dietary - pharmacology Sympathectomy, Chemical Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology Time Urea - blood Vascular Resistance - drug effects
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Zusammenfassung:	Departments of 1 Physiology, 2 Clinical Chemistry, and 3 Pathology, Ernst-Moritz-Arndt-University, D-17487 Greifswald, Germany The effects of neonatal sympathectomy of donors or recipients on posttransplantation arterial pressure were investigated in spontaneously hypertensive rats (SHR) by renal transplantation experiments. Conscious mean arterial pressure (MAP) and renal vascular resistance were 136 ± 1 mmHg and 15.5 ± 1.2 mmHg · ml 1 · min · g in sympathectomized SHR ( n = 8) vs. 158 ± 4 mmHg ( P
ISSN:	0363-6119 1522-1490
DOI:	10.1152/ajpregu.00669.2001