Persistent Acid and Bile Reflux in Asymptomatic Patients With Barrett Esophagus Receiving Proton Pump Inhibitor Therapy

HYPOTHESIS Symptom control does not reflect elimination of abnormal acid reflux or abnormal bile reflux in patients with long-segment Barrett esophagus receiving proton pump inhibitors (PPIs). DESIGN Prospective survey. SETTING University hospital. PATIENTS Thirty-two patients with long-segment Barrett esophagus who were asymptomatic with PPIs. MAIN OUTCOME MEASURES Twenty-four–hour ambulatory pH and bile reflux monitoring while continuing PPIs. RESULTS Abnormal acid reflux (pH