The effect of diet enriched with α-linolenic acid on soluble cellular adhesion molecules in dyslipidaemic patients
Background: Leukocyte adhesion and transendothelial migration, the critical pathogenic components in the development of atherosclerotic lesions, are largely mediated by cellular adhesion molecules (CAMs). We examined whether dietary supplementation with α-linolenic acid (ALA, 18:3 n−3) affects the l...
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Veröffentlicht in: | Atherosclerosis 2004-05, Vol.174 (1), p.127-132 |
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Zusammenfassung: | Background: Leukocyte adhesion and transendothelial migration, the critical pathogenic components in the development of atherosclerotic lesions, are largely mediated by cellular adhesion molecules (CAMs). We examined whether dietary supplementation with α-linolenic acid (ALA, 18:3
n−3) affects the levels of soluble forms of CAMs in dyslipidaemic patients.
Methods: We recruited 90 male dyslipidaemic patients (mean age=51±8 years) following a typical Greek diet. They were randomly assigned either to 15
ml of linseed oil (rich in ALA) per day (
n=60) or to 15
ml of safflower oil (rich in linoleic acid [LA, 18:2
n−6]) per day (
n=30). The ratio of
n−6:
n−3 in linseed oil supplemented group was 1.3:1 and in safflower oil supplemented group 13.2:1. Dietary intervention lasted for 12 weeks. Blood lipids, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) were measured.
Results: Dietary supplementation with ALA significantly decreased sVCAM-1 levels (median decrease 18.7% [577.5
ng/ml versus 487
ng/ml,
P=0.0001]). In the LA supplemented group, sVCAM-1 was also significantly decreased but to a lesser extent (median decrease 10.6% [550.5
ng/ml versus 496
ng/ml,
P=0.0001]). After controlling for smoking habits, no significant difference was observed in the reduction of sVCAM-1 levels between the two treatment arms (
P=0.205). The decrease of sVCAM-1 was independent of lipid changes in both groups.
Conclusions: Dietary supplementation with ALA for 12 weeks significantly decreases sVCAM-1 levels in dyslipidaemic patients. This effect presents a potential mechanism for the beneficial effect of plant
n−3 polyunsaturated fatty acids in the prevention of coronary artery disease. In addition, dietary supplementation with LA significantly decreases sVCAM-1 levels, an effect which requires further investigation. |
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ISSN: | 0021-9150 1879-1484 |
DOI: | 10.1016/j.atherosclerosis.2004.01.013 |