The relationships between intestinal damage and circulating endotoxins in experimental Trypanosoma brucei brucei infections

The involvement of intestinal damage in experimental African trypanosomiasis was investigated in rats infected with Trypanosoma brucei brucei by measuring the urinary excretion of the previously administered non-metabolizable sugar probes, D-mannitol and lactulose, and the flux of FITC-dextran acros...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Parasitology 2002-06, Vol.124 (6), p.589-595
Hauptverfasser:	NYAKUNDI, J. N., CRAWLEY, B., SMITH, R. A., PENTREATH, V. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight cytokines Dextrans - metabolism Drinking Eating endotoxin levels Endotoxins Endotoxins - blood Excretion experimental African trypanosomiasis Experimental protozoal diseases and models Fluorescein-5-isothiocyanate Infectious diseases Intestinal Absorption Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lactulose - metabolism Logistic Models Male Mannitol - metabolism Medical sciences Parasitic diseases Probes Protozoal diseases Rats Rats, Wistar Sugar Trypanosoma brucei brucei Trypanosoma brucei brucei - physiology Trypanosomiasis, African - blood Trypanosomiasis, African - pathology Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The involvement of intestinal damage in experimental African trypanosomiasis was investigated in rats infected with Trypanosoma brucei brucei by measuring the urinary excretion of the previously administered non-metabolizable sugar probes, D-mannitol and lactulose, and the flux of FITC-dextran across isolated, everted gut segments. There was increased urinary recovery and flux of the sugar probes across the intestine which were significant (P
ISSN:	0031-1820 1469-8161
DOI:	10.1017/S0031182002001701