Chromosome Dynamics: New Light on Aurora B Kinase Function

Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromos...

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Veröffentlicht in:Current biology 2002-07, Vol.12 (13), p.R458-R460
Hauptverfasser: Shannon, Katie B, Salmon, E.D
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description Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromosome condensation and cohesion.
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subjects Animals
Aurora Kinase B
Aurora Kinases
Autoantigens
Caenorhabditis elegans Proteins - metabolism
Centromere Protein A
Chromosomal Proteins, Non-Histone - metabolism
Chromosome Segregation - physiology
Chromosomes - physiology
Dyneins - metabolism
Humans
Intracellular Signaling Peptides and Proteins
Kinetochores - metabolism
Microtubules - metabolism
Mitosis - physiology
Protein Kinases - metabolism
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
Saccharomyces cerevisiae Proteins
title Chromosome Dynamics: New Light on Aurora B Kinase Function
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