Chromosome Dynamics: New Light on Aurora B Kinase Function
Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromos...
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Veröffentlicht in: | Current biology 2002-07, Vol.12 (13), p.R458-R460 |
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description | Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromosome condensation and cohesion. |
doi_str_mv | 10.1016/S0960-9822(02)00945-4 |
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source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
subjects | Animals Aurora Kinase B Aurora Kinases Autoantigens Caenorhabditis elegans Proteins - metabolism Centromere Protein A Chromosomal Proteins, Non-Histone - metabolism Chromosome Segregation - physiology Chromosomes - physiology Dyneins - metabolism Humans Intracellular Signaling Peptides and Proteins Kinetochores - metabolism Microtubules - metabolism Mitosis - physiology Protein Kinases - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Saccharomyces cerevisiae Proteins |
title | Chromosome Dynamics: New Light on Aurora B Kinase Function |
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