Chromosome Dynamics: New Light on Aurora B Kinase Function

Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromos...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current biology 2002-07, Vol.12 (13), p.R458-R460
Hauptverfasser:	Shannon, Katie B, Salmon, E.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aurora Kinase B Aurora Kinases Autoantigens Caenorhabditis elegans Proteins - metabolism Centromere Protein A Chromosomal Proteins, Non-Histone - metabolism Chromosome Segregation - physiology Chromosomes - physiology Dyneins - metabolism Humans Intracellular Signaling Peptides and Proteins Kinetochores - metabolism Microtubules - metabolism Mitosis - physiology Protein Kinases - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Saccharomyces cerevisiae Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromosome condensation and cohesion.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/S0960-9822(02)00945-4