Remarkable 4,4′-Substituent Effects on Binap: Highly Enantioselective Ru Catalysts for Asymmetric Hydrogenation of β-Aryl Ketoesters and Their Immobilization in Room-Temperature Ionic Liquids

Remarkable 4,4′-Substituent Effects on Binap: Highly Enantioselective Ru Catalysts for Asymmetric Hydrogenation of β-Aryl Ketoesters and Their Immobilization in Room-Temperature Ionic Liquids

A family of chiral diphosphanes with systematically tunable electronic and steric properties have been used in the asymmetric hydrogenation of β‐aryl ketoesters with excellent ee values (up to 99.8 %) by taking advantage of remarkable 4,4′‐substituent effects on binap. These highly enantioselective...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-05, Vol.43 (19), p.2501-2504
Hauptverfasser: Hu, Aiguo, Ngo, Helen L., Lin, Wenbin
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
chirality
hydrogenation
ionic liquids
phosphanes
ruthenium
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Zusammenfassung:A family of chiral diphosphanes with systematically tunable electronic and steric properties have been used in the asymmetric hydrogenation of β‐aryl ketoesters with excellent ee values (up to 99.8 %) by taking advantage of remarkable 4,4′‐substituent effects on binap. These highly enantioselective Ru catalysts have also been effectively immobilized in room‐temperature ionic liquids (RTIL).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200353415