Lauric acid is desaturated to 12∶1n−3 by hepatocytes and rat liver homogenates

Lauric acid is desaturated to 12∶1n−3 by hepatocytes and rat liver homogenates

Lauric acid desaturation was investigated and described in liver homogenates and in cultured rat hepatocytes. The identification of the desaturated product of lauric acid has been performed using the oxidative cleavage method, and we showed that the obtained monoene was mainly 12∶1n−3. This result s...

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Veröffentlicht in:Lipids 2002-06, Vol.37 (6), p.569-572
Hauptverfasser: Legrand, Philippe, Catheline, Daniel, Rioux, Vincent, Durand, Georges
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cells, Cultured
Hepatocytes - metabolism
Lauric Acids - metabolism
Liver - metabolism
Male
Rats
Rats, Sprague-Dawley
Stearoyl-CoA Desaturase
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Zusammenfassung:Lauric acid desaturation was investigated and described in liver homogenates and in cultured rat hepatocytes. The identification of the desaturated product of lauric acid has been performed using the oxidative cleavage method, and we showed that the obtained monoene was mainly 12∶1n−3. This result suggests that lauric acid desaturation could be the first step in the biosynthesis of α‐linolenic acid in animal cells.
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-002-0934-y