CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

CARMA1, BCL-10 and MALT1 are signalling proteins that have a key role in antigen-receptor-mediated lymphocyte activation through the nuclear factor-κB pathway. Recent genetic studies have revealed additional, previously unexpected roles for these proteins in the development of B and T cells, and in...

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Veröffentlicht in:	Nature reviews. Immunology 2004-05, Vol.4 (5), p.348-359
1. Verfasser:	Thome, Margot
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Antigens Apoptosis Regulatory Proteins B-Cell CLL-Lymphoma 10 Protein B-Lymphocytes - immunology CARD Signaling Adaptor Proteins Carrier Proteins - immunology Caspases Guanylate Cyclase - immunology Humans Kinases Lymphocyte Activation - immunology Lymphocytes Lymphoma Lymphoma, B-Cell, Marginal Zone - immunology Membrane Proteins - immunology Mice Mice, Knockout Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Neoplasm Proteins - immunology NF-kappa B - immunology Phosphorylation Proteins Signal Transduction - immunology T-Lymphocytes - immunology Transcription factors
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Beschreibung
Zusammenfassung:	CARMA1, BCL-10 and MALT1 are signalling proteins that have a key role in antigen-receptor-mediated lymphocyte activation through the nuclear factor-κB pathway. Recent genetic studies have revealed additional, previously unexpected roles for these proteins in the development of B and T cells, and in the CD40- and lipopolysaccharide-dependent activation of B cells. Here, I discuss recent advances in the understanding of the molecular and biological functions of these proteins.
ISSN:	1474-1733 1474-1741
DOI:	10.1038/nri1352