Electrochemistry/Mass Spectrometry (EC/MS)-A New Tool To Study Drug Metabolism and Reaction Mechanisms

A great combination: The coupling of electrochemistry and mass spectrometry (EC/MS) opens up new possibilities in analytics—not only in biochemistry for the investigation of natural products and metabolites, but also in the screening of combinatorial libraries and the characterization of transition‐...

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Veröffentlicht in:	Angewandte Chemie International Edition 2004-05, Vol.43 (19), p.2476-2478
1. Verfasser:	Karst, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Techniques, Analytical - methods Chromatography, Liquid derivatization Electrochemistry Ferrous Compounds - chemistry liquid chromatography mass spectrometry Mass Spectrometry - instrumentation Mass Spectrometry - methods metabolism Metallocenes Metalloproteins - analysis Molecular Structure Organometallic Compounds - analysis Oxidation-Reduction Peptides - analysis Peptides - chemistry Phosphotyrosine - chemistry Tyrosine - chemistry
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Beschreibung
Zusammenfassung:	A great combination: The coupling of electrochemistry and mass spectrometry (EC/MS) opens up new possibilities in analytics—not only in biochemistry for the investigation of natural products and metabolites, but also in the screening of combinatorial libraries and the characterization of transition‐metal complexes. The mode of operation, range of application, and perspectives of the current EC/MS methods are the themes of this Highlight.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200301763