GSTP1, GSTM1, and GSTT1 genetic polymorphisms in patients with cryptogenic liver cirrhosis

We investigated glutathione S–transferase (GST) P1 Ile (105) Val, T1, and M1 polymorphisms in 45 patients with documented cryptogenic cirrhosis and 56 healthy control subjects. Polymerase chain reaction–based procedures were performed in the studied populations to confirm the genotypes of GSTT1, M1,...

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Veröffentlicht in:	Journal of gastrointestinal surgery 2004-05, Vol.8 (4), p.423-427
Hauptverfasser:	Ghobadloo, Shahrokh Mohammadzadeh, Yaghmaei, Bahram, Bakayev, Valery, Goudarzi, Hossein, Noorinayer, Babak, Rad, Farhad Haghighi, Samiy, Saeed, Aghabozorghi, Sohrab, Zali, Mohammad Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Adult Aged Confidence intervals cryptogenic cirrhosis Female Glutathione S–transferase genotype Glutathione Transferase - genetics Humans Liver cirrhosis Liver Cirrhosis - genetics Male Middle Aged Polymorphism, Genetic
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Zusammenfassung:	We investigated glutathione S–transferase (GST) P1 Ile (105) Val, T1, and M1 polymorphisms in 45 patients with documented cryptogenic cirrhosis and 56 healthy control subjects. Polymerase chain reaction–based procedures were performed in the studied populations to confirm the genotypes of GSTT1, M1, and P1. Ile/Val and Val/Val GSTP1 genotypes were more frequent in the patients with cirrhosis (n = 39, 87%) than in the control subjects (n = 10; 18%) (odds ratio [OR] 34.04; 95% confidence interval [CI] 10.70 to 108.31, P
ISSN:	1091-255X 1873-4626
DOI:	10.1016/j.gassur.2004.02.005