Intracerebral xenografts of mouse bone marrow cells in adult rats facilitate restoration of cerebral blood flow and blood–brain barrier

We examined in the present study alterations in cerebral blood flow (CBF) and blood–brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow stromal cells (BMSCs) or saline infusion in adult Sprague–Dawley rats. Laser Doppler revealed that transplanted animals ex...

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Veröffentlicht in:	Brain research 2004-05, Vol.1009 (1), p.26-33
Hauptverfasser:	Borlongan, Cesario V, Lind, Jeffrey G, Dillon-Carter, Ora, Yu, Guolong, Hadman, Martin, Cheng, Charles, Carroll, James, Hess, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood-Brain Barrier - physiology Bone Marrow Cells - physiology Bone Marrow Transplantation Brain Injuries - surgery Capillary Permeability - physiology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - physiology Cross-species Enzyme-Linked Immunosorbent Assay - methods Evans Blue Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins Immunosuppression Laser-Doppler Flowmetry - methods Luminescent Proteins - metabolism Male Mice Mice, Inbred C57BL Nerve Growth Factors - metabolism Neural transplantation Neuroprotection Rats Rats, Sprague-Dawley Recovery of Function - physiology Regional Blood Flow - physiology Stem cell Stereotaxic Techniques Striatum Time Factors Transplantation, Heterologous - methods Vertebrates: nervous system and sense organs
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Zusammenfassung:	We examined in the present study alterations in cerebral blood flow (CBF) and blood–brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow stromal cells (BMSCs) or saline infusion in adult Sprague–Dawley rats. Laser Doppler revealed that transplanted animals exhibited near normal cerebral blood flow (CBF, 150 perfusion units) at a much earlier period post-transplantation (day 4) compared to animals that received saline infusion (day 12) ( p's
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2004.02.050