The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis
The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made.
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| Veröffentlicht in: | Best practice & research. Clinical rheumatology 2004-02, Vol.18 (1), p.59-80 |
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| container_title | Best practice & research. Clinical rheumatology |
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| creator | Feldmann, Marc Brennan, Fionula M Williams, Richard O Woody, James N Maini, Ravinder N |
| description | The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made. |
| doi_str_mv | 10.1016/j.berh.2003.09.010 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1521-6942 |
| ispartof | Best practice & research. Clinical rheumatology, 2004-02, Vol.18 (1), p.59-80 |
| issn | 1521-6942 1532-1770 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals anti-TNF antibody Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Autoantibodies - analysis Autoantibodies - drug effects Clinical Trials as Topic cytokine Cytokines - drug effects Cytokines - metabolism Disease Models, Animal Humans Mice Research Design RNA, Messenger - analysis Sensitivity and Specificity Synovial Membrane - drug effects Synovial Membrane - metabolism therapy Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - therapeutic use |
| title | The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis |
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