The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis

The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made.

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Bibliographische Detailangaben
Veröffentlicht in:	Best practice & research. Clinical rheumatology 2004-02, Vol.18 (1), p.59-80
Hauptverfasser:	Feldmann, Marc, Brennan, Fionula M, Williams, Richard O, Woody, James N, Maini, Ravinder N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-TNF antibody Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Autoantibodies - analysis Autoantibodies - drug effects Clinical Trials as Topic cytokine Cytokines - drug effects Cytokines - metabolism Disease Models, Animal Humans Mice Research Design RNA, Messenger - analysis Sensitivity and Specificity Synovial Membrane - drug effects Synovial Membrane - metabolism therapy Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - therapeutic use
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Beschreibung
Zusammenfassung:	The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made.
ISSN:	1521-6942 1532-1770
DOI:	10.1016/j.berh.2003.09.010