Submandibular salivary gland volume is increased in patients with acromegaly

Summary objective Acromegaly is characterized by an enlargement of various organs. The aim of the present study was to evaluate whether acromegalic patients have an increased volume of submandibular salivary glands. design and subjects Prospective study on 40 consecutive acromegalic patients (18 mal...

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Veröffentlicht in:Clinical endocrinology (Oxford) 2002-07, Vol.57 (1), p.97-100
Hauptverfasser: Manetti, Luca, Bogazzi, Fausto, Brogioni, Sandra, Grasso, Lucia, Lupi, Isabella, Genovesi, Maura, Cecconi, Elisabetta, Gasperi, Maurizio, Martino, Enio
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Sprache:eng
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Zusammenfassung:Summary objective Acromegaly is characterized by an enlargement of various organs. The aim of the present study was to evaluate whether acromegalic patients have an increased volume of submandibular salivary glands. design and subjects Prospective study on 40 consecutive acromegalic patients (18 male, 22 female; mean age ± SD, 50 ± 13 years, range 22–74 years) submitted to submandibular salivary gland ultrasound. Among acromegalic patients, 15 had active and untreated disease (Acro‐U), 13 were under long‐acting somatostatin analogue therapy (Acro‐SA), 12 were in remission after surgery (Acro‐R). Two hundred subjects (90 male, 110 female, mean age ± SD, 50 ± 11 years, range 23–74 years) matched for age, sex and body mass index served as controls. measurements Submandibular salivary gland volume was measured in all acromegalic patients and normal subjects by ultrasound and calculated by the ellipsoid model. Serum GH and IGF‐I concentrations were measured in all subjects. results Acro‐U patients had higher serum IGF‐I levels (691 ± 235 µg/l) than Acro‐R (174 ± 74 µg/l), Acro‐SA (436 ± 239 µg/l) or controls (151 ± 66 µg/l) (P 
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.2002.01576.x