Analysis of phenotypic variation in psoriasis as a function of age at onset and family history

To evaluate the relationship between psoriasis disease severity, age at onset, and family history, we analyzed 537 US psoriatics, most of whom were from Michigan. Total body surface area involvement (%TBSA), presence or absence of joint complaints, and nail involvement were measured. Analysis of fam...

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Veröffentlicht in:	Archives of Dermatological Research 2002-07, Vol.294 (5), p.207-213
Hauptverfasser:	STUART, Philip, MALICK, Farah, NAIR, Rajan P, HENSELER, Tilo, LIM, Henry W, JENISCH, Stefan, VOORHEES, John, CHRISTOPHERS, Enno, ELDER, James T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age of Onset Aged Biological and medical sciences Child Child, Preschool Dermatology Female Haplotypes Humans Infant Infant, Newborn Joint Diseases - complications Joint Diseases - genetics Major Histocompatibility Complex Male Medical sciences Middle Aged Nails - pathology Phenotype Psoriasis - complications Psoriasis - genetics Psoriasis - pathology Psoriasis. Parapsoriasis. Lichen Risk Factors
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Zusammenfassung:	To evaluate the relationship between psoriasis disease severity, age at onset, and family history, we analyzed 537 US psoriatics, most of whom were from Michigan. Total body surface area involvement (%TBSA), presence or absence of joint complaints, and nail involvement were measured. Analysis of familial psoriatics revealed that %TBSA was 15.1% when onset was early, but only 8.7% when onset was late ( P=0.00003). The opposite trend was seen when psoriasis was sporadic: %TBSA was 14.3% when onset was early (
ISSN:	0340-3696 1432-069X
DOI:	10.1007/s00403-002-0321-3