The Budd–Chiari Syndrome

To the Editor: We would like to comment on the definitions and classification used in the comprehensive review of the Budd–Chiari syndrome by Menon et al. (Feb. 5 issue). 1 Agreement on a uniform nomenclature is an essential requirement for clinical practice and future collaborative studies. Veno-occlusive disease, also referred to as the sinusoidal obstruction syndrome, is defined as nonthrombotic obstruction of sinusoids or central hepatic veins due to toxic injury of the sinusoidal wall. 2 The epidemiology, pathophysiology, and treatment of veno-occlusive disease are so distinct from those of the Budd–Chiari syndrome that it is generally considered a separate disease entity. . . .