Urinary beta-2 microglobulin in renal dysfunction associated with hypothyroidism

Summary Hypothyroidism is associated with a number of functional renal disorders primarily affecting water and salt handling. In this study, we aim to investigate functional renal disorders in overt and subclinical hypothyroidism. We utilised urinary beta‐2 microglobulin (β2M) as a sensitive marker of tubular dysfunction. Urinary β2M excretion and tests for renal functions were repeated before and after T4 replacement therapy. Forty‐four patients (28 with overt disease, 16 with subclinical disease) and 31 healthy control subjects were involved in the study. There was a significant increase in urinary β2M in both overt and subclinical hypothyroidism (p