Optimizing the determination of haloacetic acids in drinking waters
Three methods are currently approved by the US Environmental Protection Agency for the compliance monitoring of haloacetic acids in drinking waters. Each derivatizes the acids to their corresponding esters using either acidic methanol or diazomethane. This study was undertaken to characterize the ex...
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| Veröffentlicht in: | Journal of Chromatography A 2004-04, Vol.1035 (1), p.9-16 |
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| container_title | Journal of Chromatography A |
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| creator | Domino, Mark M Pepich, Barry V Munch, David J Fair, Patricia S |
| description | Three methods are currently approved by the US Environmental Protection Agency for the compliance monitoring of haloacetic acids in drinking waters. Each derivatizes the acids to their corresponding esters using either acidic methanol or diazomethane. This study was undertaken to characterize the extent of methylation of these analytes by these methods, and to fully optimize methylation chemistries to improve analytical sensitivity, precision and accuracy. The approved methods were shown to have little to no esterification efficiencies for the brominated trihaloacetic acids (HAA3). Methylation with acidic methanol was determined to be more efficient and rugged than methylation with diazomethane. A new higher boiling solvent, tertiary-amyl methyl ether, is reported which has significantly improved methylation efficiencies for HAA3. Additional modifications to the method have been made that improve method ruggedness. The revised method, EPA Method 552.3, outperforms the currently approved methods, especially for HAA3. |
| doi_str_mv | 10.1016/j.chroma.2004.02.034 |
| format | Article |
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Each derivatizes the acids to their corresponding esters using either acidic methanol or diazomethane. This study was undertaken to characterize the extent of methylation of these analytes by these methods, and to fully optimize methylation chemistries to improve analytical sensitivity, precision and accuracy. The approved methods were shown to have little to no esterification efficiencies for the brominated trihaloacetic acids (HAA3). Methylation with acidic methanol was determined to be more efficient and rugged than methylation with diazomethane. A new higher boiling solvent, tertiary-amyl methyl ether, is reported which has significantly improved methylation efficiencies for HAA3. Additional modifications to the method have been made that improve method ruggedness. The revised method, EPA Method 552.3, outperforms the currently approved methods, especially for HAA3.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/j.chroma.2004.02.034</identifier><identifier>PMID: 15117068</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acetates - analysis ; Analysis ; Analytical biochemistry: general aspects, technics, instrumentation ; Analytical chemistry ; Analytical, structural and metabolic biochemistry ; Applied sciences ; Biological and medical sciences ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Derivatization, GC ; Diazomethane ; Esterification ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Haloacetic acids ; Medical sciences ; Methylation ; Pharmacology. Drug treatments ; Pollution ; Reproducibility of Results ; Sensitivity and Specificity ; Water analysis ; Water Supply - analysis ; Water treatment and pollution</subject><ispartof>Journal of Chromatography A, 2004-04, Vol.1035 (1), p.9-16</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-a3d76cb16bd6d92d1646711aa74491823e7d330cacb028a6fd10e689e88eea673</citedby><cites>FETCH-LOGICAL-c454t-a3d76cb16bd6d92d1646711aa74491823e7d330cacb028a6fd10e689e88eea673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021967304002341$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15622404$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15117068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domino, Mark M</creatorcontrib><creatorcontrib>Pepich, Barry V</creatorcontrib><creatorcontrib>Munch, David J</creatorcontrib><creatorcontrib>Fair, Patricia S</creatorcontrib><title>Optimizing the determination of haloacetic acids in drinking waters</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>Three methods are currently approved by the US Environmental Protection Agency for the compliance monitoring of haloacetic acids in drinking waters. Each derivatizes the acids to their corresponding esters using either acidic methanol or diazomethane. This study was undertaken to characterize the extent of methylation of these analytes by these methods, and to fully optimize methylation chemistries to improve analytical sensitivity, precision and accuracy. The approved methods were shown to have little to no esterification efficiencies for the brominated trihaloacetic acids (HAA3). Methylation with acidic methanol was determined to be more efficient and rugged than methylation with diazomethane. A new higher boiling solvent, tertiary-amyl methyl ether, is reported which has significantly improved methylation efficiencies for HAA3. Additional modifications to the method have been made that improve method ruggedness. The revised method, EPA Method 552.3, outperforms the currently approved methods, especially for HAA3.</description><subject>Acetates - analysis</subject><subject>Analysis</subject><subject>Analytical biochemistry: general aspects, technics, instrumentation</subject><subject>Analytical chemistry</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Derivatization, GC</subject><subject>Diazomethane</subject><subject>Esterification</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Haloacetic acids</subject><subject>Medical sciences</subject><subject>Methylation</subject><subject>Pharmacology. Drug treatments</subject><subject>Pollution</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Water analysis</subject><subject>Water Supply - analysis</subject><subject>Water treatment and pollution</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhj2AaCn8A4SywJZwdlw7WZBQxZeE1AVm62pfqEs-ip2C4NeTqpVgYrobnvfV3cPYGYeMA1dXq8wuQ9dgJgBkBiKDXB6wMYDgaal0PmLHMa4AuAYtjtiIT_mwqmLMZvN17xv_7dvXpF9S4qin0PgWe9-1SVclS6w7tNR7m6D1Lia-TVzw7ds28YkDHU_YYYV1pNP9nLCXu9vn2UP6NL9_nN08pVZOZZ9i7rSyC64WTrlSOK6k0pwjailLXoictMtzsGgXIApUleNAqiipKIhw-GLCLne969C9byj2pvHRUl1jS90mGs0LLSGfDqDcgTZ0MQaqzDr4BsOX4WC2wszK7ISZrTADwgzChtj5vn-zaMj9hva2BuBiD2C0WFcBW-vjH04JIWFbdL3jaLDx4SmYaD21lpwPZHvjOv__JT94RYz2</recordid><startdate>20040430</startdate><enddate>20040430</enddate><creator>Domino, Mark M</creator><creator>Pepich, Barry V</creator><creator>Munch, David J</creator><creator>Fair, Patricia S</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040430</creationdate><title>Optimizing the determination of haloacetic acids in drinking waters</title><author>Domino, Mark M ; Pepich, Barry V ; Munch, David J ; Fair, Patricia S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-a3d76cb16bd6d92d1646711aa74491823e7d330cacb028a6fd10e689e88eea673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetates - analysis</topic><topic>Analysis</topic><topic>Analytical biochemistry: general aspects, technics, instrumentation</topic><topic>Analytical chemistry</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Derivatization, GC</topic><topic>Diazomethane</topic><topic>Esterification</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Haloacetic acids</topic><topic>Medical sciences</topic><topic>Methylation</topic><topic>Pharmacology. Drug treatments</topic><topic>Pollution</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Water analysis</topic><topic>Water Supply - analysis</topic><topic>Water treatment and pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Domino, Mark M</creatorcontrib><creatorcontrib>Pepich, Barry V</creatorcontrib><creatorcontrib>Munch, David J</creatorcontrib><creatorcontrib>Fair, Patricia S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Domino, Mark M</au><au>Pepich, Barry V</au><au>Munch, David J</au><au>Fair, Patricia S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimizing the determination of haloacetic acids in drinking waters</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2004-04-30</date><risdate>2004</risdate><volume>1035</volume><issue>1</issue><spage>9</spage><epage>16</epage><pages>9-16</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>Three methods are currently approved by the US Environmental Protection Agency for the compliance monitoring of haloacetic acids in drinking waters. Each derivatizes the acids to their corresponding esters using either acidic methanol or diazomethane. This study was undertaken to characterize the extent of methylation of these analytes by these methods, and to fully optimize methylation chemistries to improve analytical sensitivity, precision and accuracy. The approved methods were shown to have little to no esterification efficiencies for the brominated trihaloacetic acids (HAA3). Methylation with acidic methanol was determined to be more efficient and rugged than methylation with diazomethane. A new higher boiling solvent, tertiary-amyl methyl ether, is reported which has significantly improved methylation efficiencies for HAA3. Additional modifications to the method have been made that improve method ruggedness. 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| subjects | Acetates - analysis Analysis Analytical biochemistry: general aspects, technics, instrumentation Analytical chemistry Analytical, structural and metabolic biochemistry Applied sciences Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Derivatization, GC Diazomethane Esterification Exact sciences and technology Fundamental and applied biological sciences. Psychology General pharmacology Haloacetic acids Medical sciences Methylation Pharmacology. Drug treatments Pollution Reproducibility of Results Sensitivity and Specificity Water analysis Water Supply - analysis Water treatment and pollution |
| title | Optimizing the determination of haloacetic acids in drinking waters |
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