ATP is a key mediator of central and peripheral chemosensory transduction
Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within the carotid body) chemosensoryâtransduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for...
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description | Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within
the carotid body) chemosensoryâtransduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for ATP are expressed within the ventrolateral medulla as well as by the peripheral
chemosensory afferent neurones. Blockade of P2 receptors in the ventrolateral medulla attenuates the CO 2 -induced increase in respiration while blockade of purinergic signalling impairs carotid body function and diminishes the
ventilatory response to hypoxia. Furthermore, ATP is released from the ventral surface of the medulla during hypercapnia and
from the carotid body during hypoxia. Finally, exogenous ATP applied on the ventral surface of the medulla evokes rapid increase
in phrenic nerve activity, while ATP applied to the carotid body evokes marked excitation of the carotid sinus nerve afferents.
We suggest that in the ventrolateral medulla ATP is produced following CO 2 /H + -induced activation of central chemosensory elements (neuronal and/or glial) and acts within the respiratory network to produce
physiologically relevant changes in ventilation. In the carotid body, ATP contributes in a significant manner to the transmission
of the sensitivity of the carotid body to changes in arterial P O 2 and may be considered as a key transmitter released by chemoreceptor cells to activate endings of the sinus nerve afferent
fibres. |
doi_str_mv | 10.1113/expphysiol.2003.002659 |
format | Article |
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the carotid body) chemosensoryâtransduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for ATP are expressed within the ventrolateral medulla as well as by the peripheral
chemosensory afferent neurones. Blockade of P2 receptors in the ventrolateral medulla attenuates the CO 2 -induced increase in respiration while blockade of purinergic signalling impairs carotid body function and diminishes the
ventilatory response to hypoxia. Furthermore, ATP is released from the ventral surface of the medulla during hypercapnia and
from the carotid body during hypoxia. Finally, exogenous ATP applied on the ventral surface of the medulla evokes rapid increase
in phrenic nerve activity, while ATP applied to the carotid body evokes marked excitation of the carotid sinus nerve afferents.
We suggest that in the ventrolateral medulla ATP is produced following CO 2 /H + -induced activation of central chemosensory elements (neuronal and/or glial) and acts within the respiratory network to produce
physiologically relevant changes in ventilation. In the carotid body, ATP contributes in a significant manner to the transmission
of the sensitivity of the carotid body to changes in arterial P O 2 and may be considered as a key transmitter released by chemoreceptor cells to activate endings of the sinus nerve afferent
fibres.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.2003.002659</identifier><identifier>PMID: 15109209</identifier><language>eng</language><publisher>9600 Garsington Road , Oxford , OX4 2DQ , UK: The Physiological Society</publisher><subject>Adenosine Triphosphate - metabolism ; Animals ; Carotid Body - physiology ; Chemoreceptor Cells - physiology ; Medulla Oblongata - physiology ; Signal Transduction - physiology</subject><ispartof>Experimental physiology, 2004-01, Vol.89 (1), p.53-59</ispartof><rights>2004 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4697-db8348b2677b829f44c35591e5a72e1ea4e5959a7930c86ca35ce0ef41be487f3</citedby><cites>FETCH-LOGICAL-c4697-db8348b2677b829f44c35591e5a72e1ea4e5959a7930c86ca35ce0ef41be487f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.2003.002659$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.2003.002659$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15109209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spyer, K. Michael</creatorcontrib><creatorcontrib>Dale, Nicholas</creatorcontrib><creatorcontrib>Gourine, Alexander V.</creatorcontrib><title>ATP is a key mediator of central and peripheral chemosensory transduction</title><title>Experimental physiology</title><addtitle>Exp Physiol</addtitle><description>Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within
the carotid body) chemosensoryâtransduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for ATP are expressed within the ventrolateral medulla as well as by the peripheral
chemosensory afferent neurones. Blockade of P2 receptors in the ventrolateral medulla attenuates the CO 2 -induced increase in respiration while blockade of purinergic signalling impairs carotid body function and diminishes the
ventilatory response to hypoxia. Furthermore, ATP is released from the ventral surface of the medulla during hypercapnia and
from the carotid body during hypoxia. Finally, exogenous ATP applied on the ventral surface of the medulla evokes rapid increase
in phrenic nerve activity, while ATP applied to the carotid body evokes marked excitation of the carotid sinus nerve afferents.
We suggest that in the ventrolateral medulla ATP is produced following CO 2 /H + -induced activation of central chemosensory elements (neuronal and/or glial) and acts within the respiratory network to produce
physiologically relevant changes in ventilation. In the carotid body, ATP contributes in a significant manner to the transmission
of the sensitivity of the carotid body to changes in arterial P O 2 and may be considered as a key transmitter released by chemoreceptor cells to activate endings of the sinus nerve afferent
fibres.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Carotid Body - physiology</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Medulla Oblongata - physiology</subject><subject>Signal Transduction - physiology</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhq2qVVlo_wLypVUv2Y5jO7a5IUQLEhIcqNSb5XgnjSEbp3ZWNP--WbISN8RpNNLzzsdDyCmDNWOMf8d_w9BOOcRuXQLwNUBZSfOOrJioTCGE_P2erMBIXUCl4Igc5_wAwDho8ZEcMcnAlGBW5Pr8_o6GTB19xIlucRPcGBONDfXYj8l11PUbOmAKQ4v71re4jRn7HNNEZ6DPm50fQ-w_kQ-N6zJ-PtQT8uvH5f3FVXFz-_P64vym8PNlqtjUmgtdl5VStS5NI4TnUhqG0qkSGTqB0kjjlOHgdeUdlx4BG8FqFFo1_IR8XeYOKf7dYR7tNmSPXed6jLtsFdOV0aBm8NurINOGaVUaLWa0WlCfYs4JGzuksHVpsgzs3rd98W33vu3iew6eHnbs6lneS-wgeAbOFuApdDi9cay9vLuC5w--LOE2_GmfQkK7wDn6gONktbHMSs7_A0cxnvs</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Spyer, K. Michael</creator><creator>Dale, Nicholas</creator><creator>Gourine, Alexander V.</creator><general>The Physiological Society</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>ATP is a key mediator of central and peripheral chemosensory transduction</title><author>Spyer, K. Michael ; Dale, Nicholas ; Gourine, Alexander V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4697-db8348b2677b829f44c35591e5a72e1ea4e5959a7930c86ca35ce0ef41be487f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Carotid Body - physiology</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Medulla Oblongata - physiology</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spyer, K. Michael</creatorcontrib><creatorcontrib>Dale, Nicholas</creatorcontrib><creatorcontrib>Gourine, Alexander V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spyer, K. Michael</au><au>Dale, Nicholas</au><au>Gourine, Alexander V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ATP is a key mediator of central and peripheral chemosensory transduction</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp Physiol</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>89</volume><issue>1</issue><spage>53</spage><epage>59</epage><pages>53-59</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within
the carotid body) chemosensoryâtransduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for ATP are expressed within the ventrolateral medulla as well as by the peripheral
chemosensory afferent neurones. Blockade of P2 receptors in the ventrolateral medulla attenuates the CO 2 -induced increase in respiration while blockade of purinergic signalling impairs carotid body function and diminishes the
ventilatory response to hypoxia. Furthermore, ATP is released from the ventral surface of the medulla during hypercapnia and
from the carotid body during hypoxia. Finally, exogenous ATP applied on the ventral surface of the medulla evokes rapid increase
in phrenic nerve activity, while ATP applied to the carotid body evokes marked excitation of the carotid sinus nerve afferents.
We suggest that in the ventrolateral medulla ATP is produced following CO 2 /H + -induced activation of central chemosensory elements (neuronal and/or glial) and acts within the respiratory network to produce
physiologically relevant changes in ventilation. In the carotid body, ATP contributes in a significant manner to the transmission
of the sensitivity of the carotid body to changes in arterial P O 2 and may be considered as a key transmitter released by chemoreceptor cells to activate endings of the sinus nerve afferent
fibres.</abstract><cop>9600 Garsington Road , Oxford , OX4 2DQ , UK</cop><pub>The Physiological Society</pub><pmid>15109209</pmid><doi>10.1113/expphysiol.2003.002659</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adenosine Triphosphate - metabolism Animals Carotid Body - physiology Chemoreceptor Cells - physiology Medulla Oblongata - physiology Signal Transduction - physiology |
title | ATP is a key mediator of central and peripheral chemosensory transduction |
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