ATP is a key mediator of central and peripheral chemosensory transduction

Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within the carotid body) chemosensory transduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Experimental physiology 2004-01, Vol.89 (1), p.53-59
Hauptverfasser: Spyer, K. Michael, Dale, Nicholas, Gourine, Alexander V.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 59
container_issue 1
container_start_page 53
container_title Experimental physiology
container_volume 89
creator Spyer, K. Michael
Dale, Nicholas
Gourine, Alexander V.
description Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within the carotid body) chemosensory transduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for ATP are expressed within the ventrolateral medulla as well as by the peripheral chemosensory afferent neurones. Blockade of P2 receptors in the ventrolateral medulla attenuates the CO 2 -induced increase in respiration while blockade of purinergic signalling impairs carotid body function and diminishes the ventilatory response to hypoxia. Furthermore, ATP is released from the ventral surface of the medulla during hypercapnia and from the carotid body during hypoxia. Finally, exogenous ATP applied on the ventral surface of the medulla evokes rapid increase in phrenic nerve activity, while ATP applied to the carotid body evokes marked excitation of the carotid sinus nerve afferents. We suggest that in the ventrolateral medulla ATP is produced following CO 2 /H + -induced activation of central chemosensory elements (neuronal and/or glial) and acts within the respiratory network to produce physiologically relevant changes in ventilation. In the carotid body, ATP contributes in a significant manner to the transmission of the sensitivity of the carotid body to changes in arterial P O 2 and may be considered as a key transmitter released by chemoreceptor cells to activate endings of the sinus nerve afferent fibres.
doi_str_mv 10.1113/expphysiol.2003.002659
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71869807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71869807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4697-db8348b2677b829f44c35591e5a72e1ea4e5959a7930c86ca35ce0ef41be487f3</originalsourceid><addsrcrecordid>eNqNkE1P3DAQhq2qVVlo_wLypVUv2Y5jO7a5IUQLEhIcqNSb5XgnjSEbp3ZWNP--WbISN8RpNNLzzsdDyCmDNWOMf8d_w9BOOcRuXQLwNUBZSfOOrJioTCGE_P2erMBIXUCl4Igc5_wAwDho8ZEcMcnAlGBW5Pr8_o6GTB19xIlucRPcGBONDfXYj8l11PUbOmAKQ4v71re4jRn7HNNEZ6DPm50fQ-w_kQ-N6zJ-PtQT8uvH5f3FVXFz-_P64vym8PNlqtjUmgtdl5VStS5NI4TnUhqG0qkSGTqB0kjjlOHgdeUdlx4BG8FqFFo1_IR8XeYOKf7dYR7tNmSPXed6jLtsFdOV0aBm8NurINOGaVUaLWa0WlCfYs4JGzuksHVpsgzs3rd98W33vu3iew6eHnbs6lneS-wgeAbOFuApdDi9cay9vLuC5w--LOE2_GmfQkK7wDn6gONktbHMSs7_A0cxnvs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1891872984</pqid></control><display><type>article</type><title>ATP is a key mediator of central and peripheral chemosensory transduction</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Spyer, K. Michael ; Dale, Nicholas ; Gourine, Alexander V.</creator><creatorcontrib>Spyer, K. Michael ; Dale, Nicholas ; Gourine, Alexander V.</creatorcontrib><description>Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within the carotid body) chemosensory transduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for ATP are expressed within the ventrolateral medulla as well as by the peripheral chemosensory afferent neurones. Blockade of P2 receptors in the ventrolateral medulla attenuates the CO 2 -induced increase in respiration while blockade of purinergic signalling impairs carotid body function and diminishes the ventilatory response to hypoxia. Furthermore, ATP is released from the ventral surface of the medulla during hypercapnia and from the carotid body during hypoxia. Finally, exogenous ATP applied on the ventral surface of the medulla evokes rapid increase in phrenic nerve activity, while ATP applied to the carotid body evokes marked excitation of the carotid sinus nerve afferents. We suggest that in the ventrolateral medulla ATP is produced following CO 2 /H + -induced activation of central chemosensory elements (neuronal and/or glial) and acts within the respiratory network to produce physiologically relevant changes in ventilation. In the carotid body, ATP contributes in a significant manner to the transmission of the sensitivity of the carotid body to changes in arterial P O 2 and may be considered as a key transmitter released by chemoreceptor cells to activate endings of the sinus nerve afferent fibres.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.2003.002659</identifier><identifier>PMID: 15109209</identifier><language>eng</language><publisher>9600 Garsington Road , Oxford , OX4 2DQ , UK: The Physiological Society</publisher><subject>Adenosine Triphosphate - metabolism ; Animals ; Carotid Body - physiology ; Chemoreceptor Cells - physiology ; Medulla Oblongata - physiology ; Signal Transduction - physiology</subject><ispartof>Experimental physiology, 2004-01, Vol.89 (1), p.53-59</ispartof><rights>2004 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4697-db8348b2677b829f44c35591e5a72e1ea4e5959a7930c86ca35ce0ef41be487f3</citedby><cites>FETCH-LOGICAL-c4697-db8348b2677b829f44c35591e5a72e1ea4e5959a7930c86ca35ce0ef41be487f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.2003.002659$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.2003.002659$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15109209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spyer, K. Michael</creatorcontrib><creatorcontrib>Dale, Nicholas</creatorcontrib><creatorcontrib>Gourine, Alexander V.</creatorcontrib><title>ATP is a key mediator of central and peripheral chemosensory transduction</title><title>Experimental physiology</title><addtitle>Exp Physiol</addtitle><description>Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within the carotid body) chemosensory transduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for ATP are expressed within the ventrolateral medulla as well as by the peripheral chemosensory afferent neurones. Blockade of P2 receptors in the ventrolateral medulla attenuates the CO 2 -induced increase in respiration while blockade of purinergic signalling impairs carotid body function and diminishes the ventilatory response to hypoxia. Furthermore, ATP is released from the ventral surface of the medulla during hypercapnia and from the carotid body during hypoxia. Finally, exogenous ATP applied on the ventral surface of the medulla evokes rapid increase in phrenic nerve activity, while ATP applied to the carotid body evokes marked excitation of the carotid sinus nerve afferents. We suggest that in the ventrolateral medulla ATP is produced following CO 2 /H + -induced activation of central chemosensory elements (neuronal and/or glial) and acts within the respiratory network to produce physiologically relevant changes in ventilation. In the carotid body, ATP contributes in a significant manner to the transmission of the sensitivity of the carotid body to changes in arterial P O 2 and may be considered as a key transmitter released by chemoreceptor cells to activate endings of the sinus nerve afferent fibres.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Carotid Body - physiology</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Medulla Oblongata - physiology</subject><subject>Signal Transduction - physiology</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhq2qVVlo_wLypVUv2Y5jO7a5IUQLEhIcqNSb5XgnjSEbp3ZWNP--WbISN8RpNNLzzsdDyCmDNWOMf8d_w9BOOcRuXQLwNUBZSfOOrJioTCGE_P2erMBIXUCl4Igc5_wAwDho8ZEcMcnAlGBW5Pr8_o6GTB19xIlucRPcGBONDfXYj8l11PUbOmAKQ4v71re4jRn7HNNEZ6DPm50fQ-w_kQ-N6zJ-PtQT8uvH5f3FVXFz-_P64vym8PNlqtjUmgtdl5VStS5NI4TnUhqG0qkSGTqB0kjjlOHgdeUdlx4BG8FqFFo1_IR8XeYOKf7dYR7tNmSPXed6jLtsFdOV0aBm8NurINOGaVUaLWa0WlCfYs4JGzuksHVpsgzs3rd98W33vu3iew6eHnbs6lneS-wgeAbOFuApdDi9cay9vLuC5w--LOE2_GmfQkK7wDn6gONktbHMSs7_A0cxnvs</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Spyer, K. Michael</creator><creator>Dale, Nicholas</creator><creator>Gourine, Alexander V.</creator><general>The Physiological Society</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>ATP is a key mediator of central and peripheral chemosensory transduction</title><author>Spyer, K. Michael ; Dale, Nicholas ; Gourine, Alexander V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4697-db8348b2677b829f44c35591e5a72e1ea4e5959a7930c86ca35ce0ef41be487f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Carotid Body - physiology</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Medulla Oblongata - physiology</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spyer, K. Michael</creatorcontrib><creatorcontrib>Dale, Nicholas</creatorcontrib><creatorcontrib>Gourine, Alexander V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spyer, K. Michael</au><au>Dale, Nicholas</au><au>Gourine, Alexander V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ATP is a key mediator of central and peripheral chemosensory transduction</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp Physiol</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>89</volume><issue>1</issue><spage>53</spage><epage>59</epage><pages>53-59</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>Recent evidence suggests that ATP is a mediator of central (within the ventral surface of the medulla) and peripheral (within the carotid body) chemosensory transduction. This short review discusses the data obtained in experiments in vivo and in vitro supporting this hypothesis. P2 receptors for ATP are expressed within the ventrolateral medulla as well as by the peripheral chemosensory afferent neurones. Blockade of P2 receptors in the ventrolateral medulla attenuates the CO 2 -induced increase in respiration while blockade of purinergic signalling impairs carotid body function and diminishes the ventilatory response to hypoxia. Furthermore, ATP is released from the ventral surface of the medulla during hypercapnia and from the carotid body during hypoxia. Finally, exogenous ATP applied on the ventral surface of the medulla evokes rapid increase in phrenic nerve activity, while ATP applied to the carotid body evokes marked excitation of the carotid sinus nerve afferents. We suggest that in the ventrolateral medulla ATP is produced following CO 2 /H + -induced activation of central chemosensory elements (neuronal and/or glial) and acts within the respiratory network to produce physiologically relevant changes in ventilation. In the carotid body, ATP contributes in a significant manner to the transmission of the sensitivity of the carotid body to changes in arterial P O 2 and may be considered as a key transmitter released by chemoreceptor cells to activate endings of the sinus nerve afferent fibres.</abstract><cop>9600 Garsington Road , Oxford , OX4 2DQ , UK</cop><pub>The Physiological Society</pub><pmid>15109209</pmid><doi>10.1113/expphysiol.2003.002659</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0958-0670
ispartof Experimental physiology, 2004-01, Vol.89 (1), p.53-59
issn 0958-0670
1469-445X
language eng
recordid cdi_proquest_miscellaneous_71869807
source Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Adenosine Triphosphate - metabolism
Animals
Carotid Body - physiology
Chemoreceptor Cells - physiology
Medulla Oblongata - physiology
Signal Transduction - physiology
title ATP is a key mediator of central and peripheral chemosensory transduction
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T22%3A42%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=ATP%20is%20a%20key%20mediator%20of%20central%20and%20peripheral%20chemosensory%20transduction&rft.jtitle=Experimental%20physiology&rft.au=Spyer,%20K.%20Michael&rft.date=2004-01-01&rft.volume=89&rft.issue=1&rft.spage=53&rft.epage=59&rft.pages=53-59&rft.issn=0958-0670&rft.eissn=1469-445X&rft_id=info:doi/10.1113/expphysiol.2003.002659&rft_dat=%3Cproquest_cross%3E71869807%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1891872984&rft_id=info:pmid/15109209&rfr_iscdi=true