Synthesis of (2S,3R)-[3',3',3'-2H3]-valine and (2S,3S)-4-fluorovaline

Synthesis of (2S,3R)-[3',3',3'-2H3]-valine and (2S,3S)-4-fluorovaline

A new synthesis of (2S,3R)-[3',3',3'-2H3]-valine has been completed and (2S,3S)-4-fluorovaline has been synthesised for the first time. Both compounds have been prepared by routes involving stereoselective addition to the (S)-pyroglutamate derivative and are available for studies in s...

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Veröffentlicht in:Organic & biomolecular chemistry 2004-05, Vol.2 (9), p.1310-1314
Hauptverfasser: Charrier, Jean-Damien, Hitchcock, Peter B, Young, Douglas W
Format: Artikel
Sprache:eng
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Zusammenfassung:A new synthesis of (2S,3R)-[3',3',3'-2H3]-valine has been completed and (2S,3S)-4-fluorovaline has been synthesised for the first time. Both compounds have been prepared by routes involving stereoselective addition to the (S)-pyroglutamate derivative and are available for studies in several areas of bio-organic chemistry.
ISSN:1477-0520
1477-0539
DOI:10.1039/b401646g