Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar

Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar

The clinical efficacy of chloroquine was assessed in the Primary Health Centre of Ankazobe, Central Highlands of Madagascar. This study shows an increase in the level of chloroquine resistance with the appearance of early treatment failures and RIII resistance. Furthermore, the prevalence of clinica...

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Veröffentlicht in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2004-05, Vol.98 (5), p.311-314
Hauptverfasser: Willcox, M.L, Rakotondrazafy, E, Andriamanalimanana, R, Andrianasolo, D, Rasoanaivo, P
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Antimalarials - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Chloroquine
Chloroquine - therapeutic use
Clinical efficacy
Drug Resistance
Female
Follow-Up Studies
Human protozoal diseases
Humans
Infectious diseases
Madagascar
Madagascar Highlands
Malaria
Malaria - drug therapy
Male
Medical sciences
Middle Aged
Parasitic diseases
Protozoal diseases
Treatment Failure
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Zusammenfassung:The clinical efficacy of chloroquine was assessed in the Primary Health Centre of Ankazobe, Central Highlands of Madagascar. This study shows an increase in the level of chloroquine resistance with the appearance of early treatment failures and RIII resistance. Furthermore, the prevalence of clinical treatment failures is approaching the level of 25%, at which WHO recommends a change of first-line drug.
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2003.10.002