Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients

Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation b...

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Veröffentlicht in:	Leukemia research 2004-04, Vol.28 (4), p.367-372
Hauptverfasser:	Galimberti, Sara, Guerrini, Francesca, Palumbo, Giuseppe Alberto, Consoli, Ugo, Fazzi, Rita, Morabito, Fortunato, Santini, Valeria, Petrini, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AML ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics BCRP Biomarkers, Tumor - analysis Female Gene Expression Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Male MDR1 Middle Aged Multidrug resistance Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Prognosis Quantitative PCR Real-time PCR Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis
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Zusammenfassung:	Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2003.09.002