Ligand efficiency: a useful metric for lead selection

Ligand efficiency: a useful metric for lead selection

Potency is not the only consideration when selecting a lead compound for further optimization into a drug, but it does hold a powerful attraction to the medicinal chemist.

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Bibliographische Detailangaben
Veröffentlicht in:Drug discovery today 2004-05, Vol.9 (10), p.430-431
Hauptverfasser: Hopkins, Andrew L., Groom, Colin R., Alex, Alexander
Format: Artikel
Sprache:eng
Schlagworte:
Drug Design
drugs
lead optimization
Ligands
Models, Biological
Models, Molecular
Pharmaceutical Preparations - chemistry
potency
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Beschreibung
Zusammenfassung:Potency is not the only consideration when selecting a lead compound for further optimization into a drug, but it does hold a powerful attraction to the medicinal chemist.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(04)03069-7