Blood ‘n’ guts: an update on schistosome digestive peptidases

Peptidases (proteolytic enzymes) found in the gut of schistosomes digest host blood proteins and facilitate the maintenance of optimal nutritional and reproductive status. We review the latest information regarding these peptidases, including their individual biochemical and biophysical characterist...

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Veröffentlicht in:	Trends in parasitology 2004-05, Vol.20 (5), p.241-248
Hauptverfasser:	Caffrey, Conor R., McKerrow, James H., Salter, Jason P., Sajid, Mohammed
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Digestive System - enzymology Diseases caused by trematodes Erythrocytes - parasitology Fundamental and applied biological sciences. Psychology Helminthic diseases Host parasite relation pathogenicity Infectious diseases Invertebrates Medical sciences Nemathelminthia. Plathelmintha Parasitic diseases Peptide Hydrolases - metabolism Schistosoma japonicum - enzymology Schistosoma mansoni - enzymology Schistosomiases
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Beschreibung
Zusammenfassung:	Peptidases (proteolytic enzymes) found in the gut of schistosomes digest host blood proteins and facilitate the maintenance of optimal nutritional and reproductive status. We review the latest information regarding these peptidases, including their individual biochemical and biophysical characteristics, and their possible interactions in vivo. The crucial issues of functional redundancy and suitability as drug targets are also discussed with respect to recent advances in genetic and chemical technologies.
ISSN:	1471-4922 1471-5007
DOI:	10.1016/j.pt.2004.03.004