Convolutindole A and Convolutamine H, New Nematocidal Brominated Alkaloids from the Marine Bryozoan Amathia convoluta

Nematocidal activity of an extract of the marine bryozoan Amathia convoluta, collected from Tasmania's east coast, was ascribed to two novel tribrominated alkaloids: convolutamine H (2) and convolutindole A (5), an indole possessing the unusual N-methoxy moiety. The structures were established...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-06, Vol.65 (6), p.938-941
Hauptverfasser:	Narkowicz, Christian K, Blackman, Adrian J, Lacey, Ernest, Gill, Jennifer H, Heiland, Kirstin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amathia convoluta Animals Anti-Bacterial Agents Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antinematodal Agents - chemistry Antinematodal Agents - isolation & purification Antinematodal Agents - pharmacology Bacillus subtilis - drug effects Biological and medical sciences Bryozoa - chemistry Chromatography, Liquid Convolutindole A Convolutindole H General pharmacology Haemonchus - drug effects Hydrocarbons, Brominated - chemistry Hydrocarbons, Brominated - isolation & purification Hydrocarbons, Brominated - pharmacology Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology Levamisole - chemistry Marine Medical sciences Molecular Conformation Molecular Structure natural products Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Saccharomyces cerevisiae - drug effects Tasmania
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Zusammenfassung:	Nematocidal activity of an extract of the marine bryozoan Amathia convoluta, collected from Tasmania's east coast, was ascribed to two novel tribrominated alkaloids: convolutamine H (2) and convolutindole A (5), an indole possessing the unusual N-methoxy moiety. The structures were established by spectroscopic techniques.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np010574x