Redox Metals in Alzheimer's Disease

Redox Metals in Alzheimer's Disease

: Redox metals in the brain play many important roles in maintenance of cellular function. The maintenance of their homeostasis is of paramount importance to a number of diseases such as Alzheimer's disease and multiple sclerosis. Iron, copper, and zinc are metals of special interest in the pat...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2004-03, Vol.1012 (1), p.171-178
Hauptverfasser: TODORICH, BOZHO M., CONNOR, JAMES R.
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer Disease - complications
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Alzheimer's disease (AD)
brain
Chelating Agents - therapeutic use
copper
Copper - metabolism
Hemochromatosis - complications
Hemochromatosis - genetics
Hemochromatosis - metabolism
Humans
iron
Iron - metabolism
Metals - metabolism
Oxidation-Reduction
redox metal
zinc
Zinc - metabolism
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Beschreibung
Zusammenfassung:: Redox metals in the brain play many important roles in maintenance of cellular function. The maintenance of their homeostasis is of paramount importance to a number of diseases such as Alzheimer's disease and multiple sclerosis. Iron, copper, and zinc are metals of special interest in the pathogenesis of these disorders. This review will focus primarily on iron.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1306.014