New chromanone acids with antibacterial activity from Calophyllum brasiliense

Six novel chromanone acids (1-6) were isolated from the bark of Calophyllum brasiliense Cambess. Their structures were elucidated on the basis of 1D and 2D NMR experiments, as well as mass spectrometry. All compounds showed moderate to strong antibacterial activity against Bacillus cereus and Staphy...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-04, Vol.67 (4), p.537-541
Hauptverfasser:	Cottiglia, F, Dhanapal, B, Sticher, O, Heilmann, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacillus cereus Bacillus cereus - drug effects Biological and medical sciences Calophyllum - chemistry Calophyllum brasiliense Chromones - chemistry Chromones - isolation & purification Chromones - pharmacology Drug Screening Assays, Antitumor General pharmacology Humans Jurkat Cells KB Cells Mass Spectrometry Medical sciences Mexico Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Staphylococcus epidermidis Staphylococcus epidermidis - drug effects
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Zusammenfassung:	Six novel chromanone acids (1-6) were isolated from the bark of Calophyllum brasiliense Cambess. Their structures were elucidated on the basis of 1D and 2D NMR experiments, as well as mass spectrometry. All compounds showed moderate to strong antibacterial activity against Bacillus cereus and Staphylococcus epidermidis, with 1 and 2 being most active. None of the compounds were cytotoxic against KB, Jurkat T, and myosarcoma cancer cells up to 20 microg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np030438n