A Strategy for Exploiting the Pseudosymmetry of the C1−C13 Stretch of Discodermolide

A Strategy for Exploiting the Pseudosymmetry of the C1−C13 Stretch of Discodermolide

The pseudo-C 2 symmetry of the C1 to C13 stretch of the discodermolide structure offers a potential strategic advantage for synthetic design. Two approaches based on this recognition were devised, and one was shown to be effective in a model series.

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Veröffentlicht in:Organic letters 2004-04, Vol.6 (9), p.1413-1416
Hauptverfasser: Parker, Kathlyn A, Katsoulis, Ioannis A
Format: Artikel
Sprache:eng
Schlagworte:
Alkanes - chemical synthesis
Alkanes - chemistry
Carbamates - chemical synthesis
Carbamates - chemistry
Lactones - chemical synthesis
Lactones - chemistry
Models, Molecular
Molecular Conformation
Pyrones
Stereoisomerism
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Beschreibung
Zusammenfassung:The pseudo-C 2 symmetry of the C1 to C13 stretch of the discodermolide structure offers a potential strategic advantage for synthetic design. Two approaches based on this recognition were devised, and one was shown to be effective in a model series.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol049735p